Search Ontology:
ChEBI

dasatinib (anhydrous)

Term ID
CHEBI:49375
Synonyms
  • anh. dasatinib
  • anhydrous dasatinib
  • BMS Dasatinib
  • BMS-354825
  • dasatinib
  • dasatinib (anh.)
  • dasatinibum
  • N-(2-chloro-6-methylphenyl)-2-({6-[4-(2-hydroxyethyl)piperazin-1-yl]-2-methylpyrimidin-4-yl}amino)-1,3-thiazole-5-carboxamide
Definition
An aminopyrimidine that is 2-methylpyrimidine which is substituted at position 4 by the primary amino group of 2-amino-1,3-thiazole-5-carboxylic acid and at position 6 by a 4-(2-hydroxyethyl)piperazin-1-yl group, and in which the carboxylic acid group has been formally condensed with 2-chloro-6-methylaniline to afford the corresponding amide. A multi-targeted kinase inhibitor, it is used, particularly as the monohydrate, for the treatment of chronic, accelerated, or myeloid or lymphoid blast phase chronic myeloid leukemia. Note that the name 'dasatinib' is used to refer to the monohydrate (USAN) as well as to anhydrous dasatinib (INN).
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
inverse has_part
inverse is_conjugate_acid_of
is_conjugate_base_of
Phenotype
Phenotype resulting from dasatinib (anhydrous)
Phenotype where environments contain dasatinib (anhydrous)
Phenotype modified by environments containing dasatinib (anhydrous)
Human Disease / Model Data
Your Input Welcome
We welcome your input and comments. Please use this form to recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.