Search Ontology:
ChEBI
entecavir (anhydrous)
- Term ID
- CHEBI:473990
- Synonyms
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- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-1,9-dihydro-6H-purin-6-one
- entecavir
- Definition
- Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B.
- References
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- Beilstein:7692760
- CAS:142217-69-4
- DrugBank:DB00442
- Drug_Central:1019
- KEGG:D07896
- LINCS:LSM-5258
- Ontology
- ChEBI ( EBI )
- is a type of
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- has_role
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- inverse has_part
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Phenotype
Phenotype resulting from entecavir (anhydrous)
Phenotype where environments contain entecavir (anhydrous)
Phenotype modified by environments containing entecavir (anhydrous)
Human Disease / Model Data