carbidopa

Term ID

CHEBI:3395

Synonyms

• (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate
• (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate
• (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate
• (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)
• (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate
• (S)-(-)-carbidopa hydrate
• (S)-carbidopa hydrate
• carbidopa
• carbidopa hydrate
• carbidopa monohydrate
• carbidopum monohydricum
• L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate

Definition

The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.

References

• CAS:38821-49-7
• DrugBank:DB00190
• KEGG:D00558
• PMID:10841799
• Patent:DE2062285
• Patent:DE2062332
• Patent:GB940596
• Patent:US3462536

Ontology

ChEBI  ( EBI )

Resources

CTD