tibolone

Term ID

CHEBI:32223

Synonyms

• (17R)-17-hydroxy-7alpha-methyl-19-norpregn-5(10)-en-20-yn-3-one
• (7alpha,17alpha)-17-hydroxy-7-methyl-19-norpregn-5(10)-en-20-yn-3-one
• (7alpha,17beta)-17-ethynyl-17-hydroxy-7-methylestr-5(10)en-3-one
• 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one
• 17alpha-ethynyl-17beta-hydroxy-7alpha-methylestr-5(10)-en-3-one
• tibolona
• tibolone
• tibolonum

Definition

Estran-3-one with a double bond between positions 5 and 10, and bearing both an ethynyl group and a hydroxy group at position 17 (R-configuration). A synthetic steroid hormone drug which acts as an agonist at all five type I steroid hormone receptors, it is used in the prevention of postmenopausal osteoporosis and for treatment of endometriosis.

References

• CAS:5630-53-5
• Drug_Central:2655
• KEGG:D01639
• Patent:US3340279
• Patent:US3475465

Ontology

ChEBI  ( EBI )