Search Ontology:
ChEBI
buprenorphine
- Term ID
- CHEBI:3216
- Synonyms
-
- (-)-buprenorphine
- (5alpha,6beta,14beta,18R)-17-(cyclopropylmethyl)-18-[(2S)-2-hydroxy-3,3-dimethylbutan-2-yl]-6-methoxy-18,19-dihydro-4,5-epoxy-6,14-ethenomorphinan-3-ol
- 17-cyclopropylmethyl-4,5alpha-epoxy-7alpha-((S)-1-hydroxy-1,2,2-trimethylpropyl)-6-methoxy-6,14-endo-ethanomorphinan-3-ol
- 2-(N-cyclopropylmethyl-4,5alpha-epoxy-3-hydroxy-6-methoxy-6,14-endo-ethanomorphinan-6alpha-yl)-3,3-dimethyl-2-butanol
- 2-[3-cyclopropylmethyl-11-hydroxy-15-methoxy-(14R)-13-oxa-3-azahexacyclo[13.2.2.12,8.01,6.06,14.07,12]icosa-7,9,11-trien-16-yl]-3,3-dimethyl-2-butanol
- 21-cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
- buprenorfina
- Buprenorphine
- buprenorphinum
- Definition
- A morphinane alkaloid that is 7,8-dihydromorphine 6-O-methyl ether in which positions 6 and 14 are joined by a -CH2CH2- bridge, one of the hydrogens of the N-methyl group is substituted by cyclopropyl, and a hydrogen at position 7 is substituted by a 2-hydroxy-3,3-dimethylbutan-2-yl group. It is highly effective for the treatment of opioid use disorder and is also increasingly being used in the treatment of chronic pain.
- References
-
- Beilstein:6182863
- CAS:52485-79-7
- Chemspider:559124
- DrugBank:DB00921
- Drug_Central:434
- HMDB:HMDB0015057
- KEGG:C08007
- KEGG:D07132
- MetaCyc:CPD-22086
- PMCID:PMC7711199
- PMID:10649968
- PMID:11303059
- PMID:15181649
- PMID:15781180
- PMID:16642964
- PMID:16650985
- PMID:17887741
- PMID:18997874
- PMID:19402772
- PMID:32925232
- PMID:33378137
- Patent:GB1136214
- Patent:US3433791
- VSDB:1789
- Wikipedia:Buprenorphine
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_role
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- inverse has_part
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Phenotype
Phenotype resulting from buprenorphine
Phenotype where environments contain buprenorphine
Phenotype modified by environments containing buprenorphine
Human Disease / Model Data