cytarabine

Term ID

CHEBI:28680

Synonyms

1-beta-D-Arabinofuranosylcytosine
4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone
4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one
ara-C
arabinocytosine
Arabinoside C
citarabina
Cytarabine
cytarabinum
Cytosine arabinoside
Cytosine-1-beta-D-arabinofuranoside
cytosine-beta-D-arabinofuranoside

Definition

A pyrimidine nucleoside in which cytosine is attached to D-arabinofuranose via a beta-N(1)-glycosidic bond. Used mainly in the treatment of leukaemia, especially acute non-lymphoblastic leukaemia, cytarabine is an antimetabolite antineoplastic agent that inhibits the synthesis of DNA. It also has antiviral and immunosuppressant properties.

References

CAS:147-94-4
DrugBank:DB00987
Drug_Central:770
HMDB:HMDB0015122
KEGG:C02961
KEGG:D00168
LINCS:LSM-5470
PDBeChem:AR3
PMID:15492802
Reaxys:89175
Wikipedia:Cytarabine

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: beta-D-arabinoside monosaccharide derivative pyrimidine nucleoside

beta-D-arabinoside monosaccharide derivative pyrimidine nucleoside Show first 5 Terms
has_functional_parent: cytosine

cytosine Show first 5 Terms
has_role: antimetabolite antineoplastic agent antiviral agent immunosuppressive agent

antimetabolite antineoplastic agent antiviral agent immunosuppressive agent Show first 5 Terms

Phenotype

Phenotype resulting from cytarabine

Phenotype where environments contain cytarabine

Phenotype modified by environments containing cytarabine

Human Disease Model