Search Ontology:
ChEBI
trioxsalen
- Term ID
- CHEBI:28329
- Synonyms
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- 2',4,8-Trimethylpsoralen
- 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
- 4,5',8-Trimethylpsoralen
- 4,8,5'-Trimethylpsoralen
- 6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
- Trimethylpsoralen
- trioxisaleno
- Trioxsalen
- trioxysalen
- trioxysalene
- trioxysalenum
- Definition
- 7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
- References
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- Beilstein:221723
- CAS:3902-71-4
- DrugBank:DB04571
- Drug_Central:2759
- KEGG:C09314
- KEGG:D01034
- KNApSAcK:C00002502
- LINCS:LSM-3223
- Patent:US3201421
- Wikipedia:Trioxsalen
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_role
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Phenotype
Phenotype resulting from trioxsalen
Phenotype where environments contain trioxsalen
Phenotype modified by environments containing trioxsalen
Human Disease / Model Data