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ChEBI

trioxsalen

Term ID
CHEBI:28329
Synonyms
  • 2',4,8-Trimethylpsoralen
  • 2,5,9-trimethyl-7H-furo[3,2-g]chromen-7-one
  • 4,5',8-Trimethylpsoralen
  • 4,8,5'-Trimethylpsoralen
  • 6-hydroxy-beta,2,7-trimethyl-5-benzofuranacrylic acid, delta-lactone
  • Trimethylpsoralen
  • trioxisaleno
  • Trioxsalen
  • trioxysalen
  • trioxysalene
  • trioxysalenum
Definition
7H-Furo[3,2-g]chromen-7-one in which positions 2, 5, and 9 are substituted by methyl groups. Like other psoralens, trioxsalen causes photosensitization of the skin. It is administered orally in conjunction with UV-A for phototherapy treatment of vitiligo. After photoactivation it creates interstrand cross-links in DNA, inhibiting DNA synthesis and cell division, and can lead to cell injury; recovery from the cell injury may be followed by increased melanisation of the epidermis.
References
  • Beilstein:221723
  • CAS:3902-71-4
  • DrugBank:DB04571
  • Drug_Central:2759
  • KEGG:C09314
  • KEGG:D01034
  • KNApSAcK:C00002502
  • LINCS:LSM-3223
  • Patent:US3201421
  • Wikipedia:Trioxsalen
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from trioxsalen
Phenotype where environments contain trioxsalen
Phenotype modified by environments containing trioxsalen
Human Disease / Model Data