oligomycin A

Term ID

CHEBI:28285

Synonyms

• (1R,4E,5'S,6S,6'S,7R,8S,10R,11R,12S,14R,15S,16R,18E,20E,22R,25S,27R,28S,29R)-22-ethyl-7,11,14,15-tetrahydroxy-6'-[(2R)-2-hydroxypropyl]-5',6,8,10,12,14,16,28,29-nonamethyl-3',4',5',6'-tetrahydro-3H,9H,13H-spiro[2,26-dioxabicyclo[23.3.1]nonacosa-4,18,20-tr
• Oligomycin A
• RP-32705

Definition

An oligomycin with formula C45H74011. An inhibitor of mitochondrial F1FO ATP synthase that induces apoptosis in a variety of cell types and exhibits antifungal, antitumour, and nematicidal activities, but its clinical application has been limited by poor solubility in water and other biocompatible solvents.

References

• CAS:579-13-5
• KEGG:C11311
• LINCS:LSM-43230
• LINCS:LSM-43272
• LINCS:LSM-43347
• MetaCyc:CPD-21956
• PDBeChem:EFO
• PMID:22869738
• PMID:233519
• PMID:24084683
• PMID:25849761
• PMID:28420869
• PMID:29650704
• Reaxys:5702132

Ontology

ChEBI  ( EBI )

Resources

CTD