Search Ontology:
ChEBI

JHU083

Term ID
CHEBI:232049
Synonyms
  • ethyl (2S)-2-[[(2S)-2-amino-4-methylpentanoyl]amino]-6-diazo-5-oxohexanoate
  • ethyl (2S)-2-{[(2S)-2-amino-4-methylpentanoyl]amino}-6-diazo-5-oxohexanoate
  • ethyl (S)-2-((S)-2-amino-4-methylpentanamido)-6-diazo-5-oxohexanoate
  • ethyl L-leucyl-6-diazo-5-oxo-L-norleucinate
  • JHU 083
  • JHU-083
Definition
An ethyl ester resulting from the formal condensation of the carboxy group of L-leucyl-6-diazo-5-oxo-L-norleucine with ethanol. It is a glutaminase inhibitor and a prodrug of 6-diazo-5-oxo-L-norleucine that exhibits antineoplastic activity.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from JHU083
Phenotype where environments contain JHU083
Phenotype modified by environments containing JHU083
Human Disease Model
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