PF-06409577

Term ID

CHEBI:231658

Synonyms

6-chloro-5-(4-(1-hydroxycyclobutyl)phenyl)-1H-indole-3-carboxylic acid
6-chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic acid
PF 06409577
PF06409577

Definition

A chloroindole that is 6-chloro-1H-indole substituted by carboxy and 4-(1-hydroxycyclobutyl)phenyl groups at positions 3 and 5, respectively. It is a potent and selective allosteric activator of AMPK and a potential treatment for diabetic nephropathy.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzenes chloroindole cyclobutanes indolecarboxylic acid tertiary alcohol

benzenes chloroindole cyclobutanes indolecarboxylic acid tertiary alcohol Show first 5 Terms
has_role: antiatherosclerotic agent antineoplastic agent EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator nephroprotective agent

antiatherosclerotic agent antineoplastic agent EC 2.7.11.31 {[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase} activator nephroprotective agent Show first 5 Terms

Phenotype

Phenotype resulting from PF-06409577

Phenotype where environments contain PF-06409577

Phenotype modified by environments containing PF-06409577

Human Disease Model