MK-2461

Term ID

CHEBI:230540

Synonyms

9-[[[(2R)-1,4-dioxan-2-yl]methyl-methylsulfamoyl]amino]-2-(1-methylpyrazol-4-yl)-11-oxobenzo[1,2]cyclohepta[2,4-b]pyridine
MK 2461
MK2461
N-[(2R)-1,4-dioxan-2-ylmethyl]-N-methyl-N'-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]sulfuric diamide

Definition

A member of the class of benzocycloheptapyridines that is 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one substituted by 1-methyl-1H-pyrazol-4-yl and [{[(2R)-1,4-dioxan-2-yl]methyl}(methyl)sulfamoyl]amino groups at positions 3 and 7, respectively. It is a novel ATP-competitive multi-targeted inhibitor of activated c-Met (IC50 = 2.5 nM).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzocycloheptapyridine dioxanes pyrazoles sulfamides

benzocycloheptapyridine dioxanes pyrazoles sulfamides Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer c-Met tyrosine kinase inhibitor

antineoplastic agent apoptosis inducer c-Met tyrosine kinase inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from MK-2461

Phenotype where environments contain MK-2461

Phenotype modified by environments containing MK-2461

Human Disease Model