GDC-0326

Term ID

CHEBI:229938

Synonyms

(2S)-2-({2-[1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}oxy)propanamide
(S)-2-((2-(1-Isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide
GDC 0326
GDC0326

Definition

An organic heterotricyclic compound that is 5,6-dihydroimidazo[1,2-d][1,4]benzoxazepine substituted by 1-(propan-2-yl)-1H-1,2,4-triazol-5-yl and [(2S)-1-amino-1-oxopropan-2-yl]oxy groups at positions 2 and 9, respectively. It is a potent and selective inhibitor of PI3Kalpha (Ki = 0.2 nM).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: ether organic heterotricyclic compound primary carboxamide tertiary amino compound triazoles

ether organic heterotricyclic compound primary carboxamide tertiary amino compound triazoles Show first 5 Terms
has_role: antineoplastic agent EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor

antineoplastic agent EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from GDC-0326

Phenotype where environments contain GDC-0326

Phenotype modified by environments containing GDC-0326

Human Disease Model