camonsertib

Term ID

CHEBI:229722

Synonyms

(3-endo)-3-{6-[(3R)-3-methylmorpholin-4-yl]-1-(1H-pyrazol-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl}-8-oxabicyclo[3.2.1]octan-3-ol
camonsertib
camonsertibum
RP 3500
RP-3500
RP3500

Definition

A pyrazolopyridine that is 1H-pyrazolo[3,4-b]pyridine substituted by 1H-pyrazol-3-yl, (3-endo)-3-hydroxy-8-oxabicyclo[3.2.1]octan-3-yl, and (3R)-3-methylmorpholin-4-yl groups at positions 1, 4 and 6, respectively. It is a highly potent and selective inhibitor of ATR kinase (IC50 = 1 nM).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: imidazoles morpholines oxabicycloalkane pyrazolopyridine tertiary alcohol

imidazoles morpholines oxabicycloalkane pyrazolopyridine tertiary alcohol Show first 5 Terms
has_role: antineoplastic agent EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor

antineoplastic agent EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from camonsertib

Phenotype where environments contain camonsertib

Phenotype modified by environments containing camonsertib

Human Disease Model