Search Ontology:
ChEBI
sparsentan
- Term ID
- CHEBI:229526
- Synonyms
-
- 2-[4-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-2-(ethoxymethyl)phenyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)benzenesulfonamide
- 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-N-(4,5-dimethyl-1,2-oxazol-3-yl)-2'-(ethoxymethyl)[biphenyl]-2-sulfonamide
- esparsentan
- Filspari
- PS 433540
- PS-433540
- PS433540
- RE-021
- sparsentan
- sparsentanum
- Definition
- A biphenyl that is 1,1'-biphenyl substituted by (4,5-dimethyl-1,2-oxazol-3-yl)aminosulfonyl, ethoxymethyl, and (2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl groups at positions 2, 2' and 4', respectively. It is a dual antagonist of endothelin and angiotensin II receptors approved for the reduction of proteinuria in adults with primary immunoglobulin A nephropathy at risk of rapid disease progression.
- References
-
- DrugBank:DB12548
- KEGG:D11776
- PMID:29142983
- PMID:30361325
- PMID:32274453
- PMID:35052766
- PMID:36852566
- PMID:37015244
- PMID:37022667
- PMID:37081176
- PMID:37140613
- PMID:37180506
- PMID:37221817
- PMID:37256677
- PMID:37278973
- PMID:37466432
- PMID:37499685
- PMID:37706310
- PMID:37850006
- PMID:37903508
- PMID:37921461
- PMID:37921485
- PMID:37931634
- PMID:38012264
- PMID:38041499
- PMID:38149041
- PMID:38271614
- PMID:38362830
- PMID:38507767
- PMID:38507768
- PMID:38507769
- PMID:38511222
- Wikipedia:Sparsentan
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Show first 5 Terms
Phenotype
Phenotype resulting from sparsentan
Phenotype where environments contain sparsentan
Phenotype modified by environments containing sparsentan
Human Disease Model