ponatinib hydrochloride

Term ID

CHEBI:191940

Synonyms

• 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide hydrochloride
• 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide--hydrogen chloride
• 4-{4-[3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzamido]-2-(trifluoromethyl)benzyl}-1-methylpiperazin-1-ium chloride
• 4-{[4-{3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methylbenzamido}-2-(trifluoromethyl)phenyl]methyl}-1-methylpiperazin-1-ium chloride
• AP 24534 hydrochloride
• AP-24534 hydrochloride
• AP24534 HCl
• Iclusig
• ponatinib HCl

Definition

The hydrochloride salt of ponatinib. It is a potent pan inhibitor of tyrosine kinases, active in all single resistance ABL kinase mutations including the T315l mutation. It is approved for the treatment of chronic myeloid leukemia.

References

• CAS:1114544-31-8
• Chemspider:28527869
• DrugBank:DBSALT000142
• KEGG:D09951
• PMID:19878872
• PMID:25970013
• PMID:28690276
• PMID:28978814
• PMID:29966620
• PMID:30705592
• PMID:34810285

Ontology

ChEBI  ( EBI )