Search Ontology:
ChEBI
midafotel
- Term ID
- CHEBI:180900
- Synonyms
-
- (2R)-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid
- (2R)-4-[(2E)-3-phosphonoprop-2-en-1-yl]piperazine-2-carboxylic acid
- (R)-4-[(E)-3-phosphonoprop-2-enyl]piperazine-2-carboxylic acid
- (R)-CPP-ene
- D(-)CPPene
- D-4-[(2E)-3-phosphono-2-propenyl]-2-piperazinecarboxylic acid
- D-CPP-ene
- D-CPPene
- midafotel
- midafotelum
- SDZ EAA 494
- SDZ-EAA 494
- SDZ-EAA-494
- Definition
- A member of the class of piperazines that is piperazine substituted by a carboxy group at position 2R and a (1E)-1-phosphonoprop-1-en-3-yl group at position 4. It is an antagonist of N-methyl-D-aspartate receptors (NMDARs) and was in clinical development by Novartis for the treatment of cognition disorders and brain injuries (now discontinued).
- References
-
- CAS:117414-74-1
- Chemspider:4940497
- PMID:10422758
- PMID:10708738
- PMID:11396518
- PMID:1480321
- PMID:15497436
- PMID:1834008
- PMID:1930876
- PMID:2147454
- PMID:2166255
- PMID:2166743
- PMID:2292244
- PMID:31563294
- PMID:32507787
- PMID:7675315
- PMID:7892415
- PMID:7894335
- PMID:7936096
- PMID:7942207
- PMID:7976650
- PMID:8194512
- PMID:8223415
- PMID:8269915
- PMID:8581475
- PMID:8740048
- PMID:8901001
- PMID:8982681
- PMID:9026366
- PMID:9721021
- PMID:9726648
- Wikipedia:Midafotel
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Show first 5 Terms
Phenotype
Phenotype resulting from midafotel
Phenotype where environments contain midafotel
Phenotype modified by environments containing midafotel
Human Disease Model