RK-24466

Term ID

CHEBI:180499

Synonyms

• 4-amino-5-(4-phenoxyphenyl)-7H-pyrrolo[3,2-d]pyrimidin-7-yl-cyclopentane
• 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
• 7-cyclopentyl-5-(4-phenoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-ylamine
• KIN 001-51
• KIN001-051
• RK 24466
• RK24466

(all 7)

Definition

A member of the class of pyrrolopyrimidines that is 7H-pyrrolo[2,3-d]pyrimidine substituted by amino, 4-phenoxyphenyl, and cyclopentyl groups at positions 4, 5 and 7, respectively. It is a potent inhibitor of Lck that inhibits Lck (64-509) and LckCD isoforms (IC50 of less than 1 and 2 nM, respectively).

References

• CAS:213743-31-8
• Chemspider:5036104
• PMID:11012021
• PMID:23505068
• PMID:24134630
• PMID:28185804

(all 6)

Ontology

ChEBI  ( EBI )