iFSP1

Term ID

CHEBI:176501

Synonyms

1-amino-3-(4-methylphenyl)pyrido[1,2-a]benzimidazole-2,4-dicarbonitrile
1-amino-3-(p-tolyl)benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile
iFSP 1
iFSP-1

Definition

A member of the class of pyridobenzimidazoles that is pyrido[1,2-a]benzimidazole substituted by amino, cyano, 4-methylphenyl, and cyano groups at positions 1, 2, 3 and 4, respectively. It is a potent inhibitor of ferroptosis suppressor protein 1 (FSP1) with EC50 of 103 nM. It induces ferroptosis in GPX4 knockout cells that overexpress FSP1.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic amine nitrile primary amino compound pyridobenzimidazole toluenes

aromatic amine nitrile primary amino compound pyridobenzimidazole toluenes Show first 5 Terms
has_role: antineoplastic agent ferroptosis inducer ferroptosis suppressor protein 1 inhibitor

antineoplastic agent ferroptosis inducer ferroptosis suppressor protein 1 inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from iFSP1

Phenotype where environments contain iFSP1

Phenotype modified by environments containing iFSP1

Human Disease Model