FIN56

Term ID

CHEBI:176419

Synonyms

FIN 56
FIN-56
N(2),N(7)-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide
N,N'-dicyclohexyl-9-(hydroxyimino)-9H-fluorene-2,7-disulfonamide

Definition

A fluorene that is N-9H-fluoren-9-ylidenehydroxylamine substituted by N-cyclohexylsulfonyl groups at positions 2 and 7. It induces ferroptosis via degradation of GPX4 and also binds and activates squalene synthase.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: fluorenes ketoxime sulfonamide

fluorenes ketoxime sulfonamide Show first 5 Terms
has_functional_parent: 9-hydroxyiminofluorene-2,7-disulfonamide

9-hydroxyiminofluorene-2,7-disulfonamide Show first 5 Terms
has_role: EC 1.11.1.9 (glutathione peroxidase) inhibitor ferroptosis inducer

EC 1.11.1.9 (glutathione peroxidase) inhibitor ferroptosis inducer Show first 5 Terms

Phenotype

Phenotype resulting from FIN56

Phenotype where environments contain FIN56

Phenotype modified by environments containing FIN56

Human Disease Model