mefuparib

Term ID

CHEBI:167905

Synonyms

5-fluoro-2-{4-[(methylamino)methyl]phenyl}-1-benzofuran-7-carboxamide
CVL-218 free base

Definition

A member of the class of 1-benzofurans that is 1-benzofuran substituted by 4-[(methylamino)methyl]phenyl, fluoro and aminocarbonyl groups at positions 2, 5, and 7, respectively. It is a potent inhibitor of poly(ADP-ribose) polymerases PARP1 and PARP2 (IC50 of 3.2 nM and 1.9 nM, respectively). The compound exhibits anti-cancer properties and has also shown promising antiviral activity against the virus that causes COVID-19.

References

CAS:1392502-82-7
Drug_Central:5378
PMID:27926532
PMID:31671946
PMID:32984792
PMID:33063092
PMID:33151287

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1-benzofurans organofluorine compound primary carboxamide secondary amino compound

1-benzofurans organofluorine compound primary carboxamide secondary amino compound Show first 5 Terms
has_role: anticoronaviral agent antineoplastic agent apoptosis inducer EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor

anticoronaviral agent antineoplastic agent apoptosis inducer EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor Show first 5 Terms
inverse is_conjugate_acid_of: mefuparib(1+)

mefuparib(1+) Show first 5 Terms
is_conjugate_base_of: mefuparib(1+)

mefuparib(1+) Show first 5 Terms

Phenotype

Phenotype resulting from mefuparib

Phenotype where environments contain mefuparib

Phenotype modified by environments containing mefuparib

Human Disease Model