Search Ontology:
ChEBI
TAK-580
- Term ID
- CHEBI:167672
- Synonyms
-
- 2-[(1R)-1-[(6-amino-5-chloropyrimidine-4-carbonyl)amino]ethyl]-N-[5-chloro-4-(trifluoromethyl)pyridin-2-yl]-1,3-thiazole-5-carboxamide
- 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide
- AMG 2112819
- AMG-2112819
- AMG2112819
- BIIB 024
- BIIB-024
- BIIB024
- DAY101
- MLN 2480
- MLN-2480
- MLN2480
- TAK 580
- TAK580
- Definition
- A 1,3-thiazolecarboxamide that is 2-[(1R)-1-aminoethyl]-1,3-thiazole-5-carboxylic acid in which the carboxy group undergoes formal condensation with the amino group of 5-chloro-4-(trifluoromethyl)pyridin-2-amine and in which the amino group undergoes formal condensation with the carboxy group of 6-amino-5-chloropyrimidine-4-carboxylic acid. It is a pan-RAF kinase inhibitor which is currently in clinical development for the treatment of radiographically recurrent or progressive low-grade glioma in children and young adults.
- References
-
- CAS:1096708-71-2
- Chemspider:28637796
- DrugBank:DB15266
- LINCS:LSM-45644
- PDBeChem:QOP
- PMCID:PMC6012010
- PMCID:PMC7715228
- PMCID:PMC7715396
- PMID:27768280
- PMID:28082416
- PMID:30622172
- PMID:32588846
- PMID:33216827
- Patent:US20090036419
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Phenotype
Phenotype resulting from TAK-580
Phenotype where environments contain TAK-580
Phenotype modified by environments containing TAK-580
Human Disease / Model Data