LB42908

Term ID

CHEBI:167660

Synonyms

(1-((1-(benzo[d][1,3]dioxol-5-ylmethyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(4-methylpiperazin-1-yl)methanone
[1-[[3-(3a,7a-dihydro-1,3-benzodioxol-5-ylmethyl)imidazol-4-yl]methyl]-4-naphthalen-1-ylpyrrol-3-yl]-(4-methylpiperazin-1-yl)methanone
[1-{[1-(1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]-methyl}-4-(1-naphtyl)-1H-pyrrol-3-yl](4-methyl-1-piperazynyl)methanone
[1-{[1-(3a,7a-dihydro-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl}-4-(naphthalen-1-yl)-1H-pyrrol-3-yl](4-methylpiperazin-1-yl)methanone
LB 42908
LB-42908

Definition

A member of the class of pyrrolecarboxamides that is 1H-pyrrole substituted by [1-(3a,7a-dihydro-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl, (4-methylpiperazin-1-yl)carbonyl, and naphthalen-1-yl groups at positions 1, 3 and 4, respectively. It is a potent inhibitor of Ras farnesyltransferase (IC50= 0.9nM against H-Ras and 2.4nM against K-Ras) with potential anticancer activity.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzodioxole imidazoles N-acylpiperazine N-methylpiperazine naphthalenes ... Show All 6 Terms

benzodioxole imidazoles N-acylpiperazine N-methylpiperazine naphthalenes pyrrolecarboxamide Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.5.1.58 (protein farnesyltransferase) inhibitor

antineoplastic agent apoptosis inducer EC 2.5.1.58 (protein farnesyltransferase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from LB42908

Phenotype where environments contain LB42908

Phenotype modified by environments containing LB42908

Human Disease Model