dextromethadone

Term ID

CHEBI:167308

Synonyms

(+)-(S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone
(+)-methadone
(6S)-6-(dimethylamino)-4,4-diphenylheptan-3-one
(6S)-methadone
(S)-(+)-methadone
(S)-6-(dimethylamino)-4,4-diphenyl-3-heptanone
(S)-methadone
d-6-(dimethylamino)-4,4-diphenyl-3-heptanone
d-methadone
REL-1017
S-(+)-methadone
S-methadone

Definition

A 6-(dimethylamino)-4,4-diphenylheptan-3-one that has (S)-configuration. It is the less active enantiomer of methadone and has very little activity on opioid receptors and mainly responsible for the inhibition of hERG K+ channels and thus for cardiac toxicity. The drug is currently under clinical development for the treatment of major depressive disorder.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 6-(dimethylamino)-4,4-diphenylheptan-3-one

6-(dimethylamino)-4,4-diphenylheptan-3-one Show first 5 Terms
has_role: NMDA receptor antagonist opioid analgesic

NMDA receptor antagonist opioid analgesic Show first 5 Terms
inverse has_part: methadone

methadone Show first 5 Terms
inverse is_enantiomer_of: levomethadone

levomethadone Show first 5 Terms
is_enantiomer_of: levomethadone

levomethadone Show first 5 Terms

Phenotype

Phenotype resulting from dextromethadone

Phenotype where environments contain dextromethadone

Phenotype modified by environments containing dextromethadone

Human Disease Model