Glu-Gly-Arg-chloromethylketone

Term ID

CHEBI:157651

Synonyms

chloromethylketone-EGR
EGR-chloromethylketone
EGR-CMK
EGRCK
Glu-Gly-Arg-chloromethylketone
glutamyl-glycyl-arginine chloromethyl ketone
H-Glu-Gly-Arg-CH2Cl
H-Glu-Gly-Arg-chloromethylketone
L-alpha-glutamyl-N-[(3S)-6-carbamimidamido-1-chloro-2-oxohexan-3-yl]glycinamide
L-Glu-Gly-L-Arg-chloromethylketone

Definition

A tripeptide composed of L-glutamic acid, glycine and L-arginine joined in sequence by peptide linkages and in which the carboxy terminus is substituted by a chloroacetyl group. It is a potent and irreversible inhibitor of urokinase-type plasminogen activator (uPA) and factor Xa.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: organochlorine compound tripeptide

organochlorine compound tripeptide Show first 5 Terms
has_functional_parent: glycine L-arginine L-glutamic acid

glycine L-arginine L-glutamic acid Show first 5 Terms
has_role: EC 3.4.21.6 (coagulation factor Xa) inhibitor

EC 3.4.21.6 (coagulation factor Xa) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from Glu-Gly-Arg-chloromethylketone

Phenotype where environments contain Glu-Gly-Arg-chloromethylketone

Phenotype modified by environments containing Glu-Gly-Arg-chloromethylketone

Human Disease Model