Search Ontology:
ChEBI

thiolutin

Term ID
CHEBI:156450
Synonyms
  • 6-acetamido-4-methyl-1,2-dithiolo[4,3-b]pyrrol-5(4H)-one
  • acetopyrrothin
  • acetopyrrothine
  • N-(4,5-dihydro-4-methyl-5-oxo-1,2-dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • N-(4-methyl-5-oxo-4,5-dihydro[1,2]dithiolo[4,3-b]pyrrol-6-yl)acetamide
  • N-(4-methyl-5-oxodithiolo[4,3-b]pyrrol-6-yl)acetamide
Definition
A dithiolopyrrolone antibiotic that is 4,5-dihydro[1,2]dithiolo[4,3-b]pyrrole in which the hydrogens at positions 4,5 and 6 have been replaced by methyl, oxo and acetamido groups, respectively. It is a potent inhibitor of RNA polymerases, inhibits the angiogenesis of human umbilical vein endothelial cells, and also inhibits JAMM metalloproteases.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from thiolutin
Phenotype where environments contain thiolutin
Phenotype modified by environments containing thiolutin
Human Disease / Model Data