tigecycline

Term ID

CHEBI:149836

Synonyms

(4S,4aS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide
(4S,4aS,5aR,12aS)-9-[(N-tert-butylglycyl)amino]-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide

Definition

Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respectively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections caused by susceptible organisms.

References

CAS:220620-09-7
DrugBank:DB00560
Drug_Central:2661
KEGG:C12012
KEGG:D01079
PMID:17194827
PMID:17210772
PMID:17220399
PMID:17307973
PMID:17353238
PMID:17353249
Reaxys:8379453

Ontology

ChEBI ( EBI )

Relationships

is a type of: tertiary alpha-hydroxy ketone tetracyclines

tertiary alpha-hydroxy ketone tetracyclines Show first 5 Terms
has_role: antibacterial drug

antibacterial drug Show first 5 Terms
inverse has_functional_parent: 11a-hydroxytigecycline(1+)

11a-hydroxytigecycline(1+) Show first 5 Terms
inverse is_conjugate_acid_of: tigecycline(1+)

tigecycline(1+) Show first 5 Terms
is_conjugate_base_of: tigecycline(1+)

tigecycline(1+) Show first 5 Terms

Phenotype

Phenotype resulting from tigecycline

Phenotype where environments contain tigecycline

Phenotype modified by environments containing tigecycline

Human Disease Model