6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil

Term ID

CHEBI:149753

Synonyms

2'-OH-ethyl-5-OP-U
6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]pyrimidine-2,4(1H,3H)-dione
6-[(2-hydroxyethyl)amino]-5-[[(1E)-2-oxopropylidene]amino]-2,4(1H,3H)-pyrimidinedione

Definition

A nucleobase analogue that is uracil substituted with a (2-hydroxyethyl)amino group at position 6 and an (E)-(2-oxopropylidene)amino group at position 5; one of 20 modifications to the potent microbial riboflavin-based metabolite antigen 5-(2-oxopropylideneamino)-6-D-ribityl aminouracil (5-OP-RU), an activator of mucosal-associated invariant T (MAIT) cells when presented by the MR1 protein (reported in MED:32123373).

References

PMID:32123373

Ontology

ChEBI ( EBI )

Relationships

is a type of: nucleobase analogue pyrimidone

nucleobase analogue pyrimidone Show first 5 Terms
has_functional_parent: uracil

uracil Show first 5 Terms
has_role: epitope

epitope Show first 5 Terms

Phenotype

Phenotype resulting from 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil

Phenotype where environments contain 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil

Phenotype modified by environments containing 6-[(2-hydroxyethyl)amino]-5-[(E)-(2-oxopropylidene)amino]uracil

Human Disease Model