10058-F4

Term ID

CHEBI:149696

Synonyms

10058F4
5-(4-ethylbenzylidene)-2-mercapto-1,3-thiazol-4(5H)-one
5-(4-ethylbenzylidene)-2-sulfanylidene-1,3-thiazolidin-4-one
5-(4-ethylbenzylidene)-2-thioxothiazolidin-4-one
5-[(4-ethylphenyl)methylene]-2-thioxo-4-thiazolidinone

Definition

A member of the class of thiazolidinones that is 2-sulfanylidene-1,3-thiazolidin-4-one which is substituted at position 5 by a (4-ethylphenyl)methylidene group. It is a cell permeable inhibitor of c-Myc-Max dimerization and exhibits antitumour effects in vivo. It downregulates c-Myc expression and upregulates CDK inhibitors, p21 and p27 resulting in the inhibition of proliferation, induction of apoptosis and cell cycle arrest in G0/G1 phase.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: olefinic compound thiazolidinone

olefinic compound thiazolidinone Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer

antineoplastic agent apoptosis inducer Show first 5 Terms

Phenotype

Phenotype resulting from 10058-F4

Phenotype where environments contain 10058-F4

Phenotype modified by environments containing 10058-F4

Human Disease / Model Data