Search Ontology:
ChEBI
remdesivir
- Term ID
- CHEBI:145994
- Synonyms
-
- (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
- 2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate
- 2-ethylbutyl N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate
- GS 5734
- GS-5734
- GS5734
- remdesivir
- remdesivirum
- Definition
- A carboxylic ester resulting from the formal condensation of the carboxy group of N-[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]-L-alanine with the hydroxy group of 2-ethylbutan-1-ol. A broad-spectrum antiviral prodrug with potent in vitro antiviral activity against a diverse panel of RNA viruses such as Ebola virus, MERS-CoV and SARS-CoV. It is currently in Phase III clinical trials for the treatment of Covid-19 in adults.
- References
-
- CAS:1809249-37-3
- DrugBank:DB14761
- KEGG:D11472
- PMCID:PMC5630887
- PMID:26934220
- PMID:28124907
- PMID:28262699
- PMID:28659436
- PMID:29511076
- PMID:30275474
- PMID:30987343
- PMID:31142680
- PMID:31233808
- PMID:31924756
- PMID:32020029
- PMID:32054787
- PMID:32094225
- PMID:32145386
- PMID:32147516
- PMID:32152082
- Wikipedia:Remdesivir
- Ontology
- ChEBI ( EBI )
- is a type of
- has_functional_parent
-
- has_role
-
Phenotype
Phenotype resulting from remdesivir
Phenotype where environments contain remdesivir
Phenotype modified by environments containing remdesivir
Human Disease Model