AS1842856

Term ID

CHEBI:145800

Synonyms

5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
AS 1842856
AS-1842856
FOXO1 inhibitor

Definition

A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: organofluorine compound primary amino compound quinolinemonocarboxylic acid quinolone secondary amino compound ... Show All 6 Terms

organofluorine compound primary amino compound quinolinemonocarboxylic acid quinolone secondary amino compound tertiary amino compound Show first 5 Terms
has_role: anti-obesity agent antineoplastic agent apoptosis inducer autophagy inhibitor forkhead box protein O1 inhibitor ... Show All 6 Terms

anti-obesity agent antineoplastic agent apoptosis inducer autophagy inhibitor forkhead box protein O1 inhibitor hypoglycemic agent Show first 5 Terms

Phenotype

Phenotype resulting from AS1842856

Phenotype where environments contain AS1842856

Phenotype modified by environments containing AS1842856

Human Disease / Model Data