glasdegib

Term ID

CHEBI:145428

Synonyms

1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea
Daurismo
glasdegib
glasdegibum
N-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-N'-(4-cyanophenyl)urea
PF-04449913
PF-4449913
PF-913

Definition

A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a (2R,4S)-4-{[(4-cyanophenyl)carbamoyl]amino}-1-methylpiperidin-2-yl group at position 2. It is a hedgehog signalling pathway inhibitor that acts by binding to Smoothened (SMO) receptors and blocking signal transduction (IC50 = 5 nM). It is used in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients (aged >= 75 years), or who have medical conditions that prevent the use of standard chemotherapy.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzimidazoles nitrile phenylureas piperidines

benzimidazoles nitrile phenylureas piperidines Show first 5 Terms
has_role: antineoplastic agent Hedgehog signaling pathway inhibitor SMO receptor antagonist

antineoplastic agent Hedgehog signaling pathway inhibitor SMO receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from glasdegib

Phenotype where environments contain glasdegib

Phenotype modified by environments containing glasdegib

Human Disease / Model Data