dinophysistoxin 1

Term ID

CHEBI:144400

Synonyms

(2R)-3-[(2S,5R,6R,8S)-8-{(2R,3E)-4-[(2R,4a'R,5R,6'S,8'R,8a'S)-6'-{(1S,3S)-3-[(2S,3R,6R,11R)-3,11-dimethyl-1,7-dioxaspiro[5.5]undecan-2-yl]-1-hydroxybutyl}-8'-hydroxy-7'-methylideneoctahydro-3H,3'H-spiro[furan-2,2'-pyrano[3,2-b]pyran]-5-yl]but-3-en-2-yl}-5
35-Methylokadaic acid
Dinophysistoxin-1
DTX 1
DTX-1
DTX1

Definition

A ketal that is a marine toxin structurally related to okadaic acid. Produced by dinoflagellates it is known to accumulate in shellfish and cause diarrhoeic shellfish poisoning. It is an inhibitor of serine/threonine protein phosphatases 1 (PP1) and PP2A and has been shown to promote cancer cell growth in tumour cell lines and animal models.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: ketal

ketal Show first 5 Terms
has_functional_parent: okadaic acid

okadaic acid Show first 5 Terms
has_role: animal metabolite EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor marine metabolite toxin

animal metabolite EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor marine metabolite toxin Show first 5 Terms

Phenotype

Phenotype resulting from dinophysistoxin 1

Phenotype where environments contain dinophysistoxin 1

Phenotype modified by environments containing dinophysistoxin 1

Human Disease Model