diflomotecan

Term ID

CHEBI:144046

Synonyms

(5R)-5-ethyl-9,10-difluoro-1,4,5,13-tetrahydro-5-hydroxy-3H,15H-oxepino(3',4':6,7)indolizino(1,2-b)quinoline-3,15-dione
(5R)-5-ethyl-9,10-difluoro-5-hydroxy-1,4,5,13-tetrahydro-3H,15H-oxepino[3',4':6,7]indolizino[1,2-b]quinoline-3,15-dione
BN 80915
BN-80915
BN80915
diflomotecan
diflomotecanum

Definition

An organic heteropentacyclic compound that is (5R)-8-[(6,7-difluoroquinolin-3-yl)methyl]-5-ethyl-5-hydroxy-1,4,5,8-tetrahydrooxepino[3,4-c]pyridine-3,9-dione in which position 7 of the oxepinopyridine moiety is joined to position 3 of the difluoroquinoine ring by a single bond. An E-ring modified camptothecin analogue that has greater lactone stability in plasma compared with other topoisomerase I inhibitors.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: epsilon-lactone organic heteropentacyclic compound organofluorine compound organonitrogen heterocyclic compound tertiary alcohol

epsilon-lactone organic heteropentacyclic compound organofluorine compound organonitrogen heterocyclic compound tertiary alcohol Show first 5 Terms
has_functional_parent: (R)-homocamptothecin

(R)-homocamptothecin Show first 5 Terms
has_role: antineoplastic agent EC 5.99.1.2 (DNA topoisomerase) inhibitor

antineoplastic agent EC 5.99.1.2 (DNA topoisomerase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from diflomotecan

Phenotype where environments contain diflomotecan

Phenotype modified by environments containing diflomotecan

Human Disease / Model Data