Search Ontology:
ChEBI

aspirin-based probe AP

Term ID
CHEBI:141699
Synonyms
  • 2-(1,3-benzothiazol-2-yl)-4-fluorophenyl 2-(acetyloxy)benzoate
  • 2-(1,3-benzothiazol-2-yl)-4-fluorophenyl 2-acetoxybenzoate
  • 2-(1,3-benzothiazol-2-yl)-4-fluorophenyl salicylate
  • probe AP
Definition
A benzoate ester resulting from the formal condensation of the carboxy group of acetylsalicylic acid with the phenolic hydroxy group of 2-(1,3-benzothiazol-2-yl)-4-fluorophenol. The latter is a fluorophore which is to the aspirin moiety via an H2O2-responsive bond. It can be used as probe for imaging H2O2 (overproduction of H2O2 causes oxidative stress and is characteristic of vascular diseases). In contrast to arylboronat-based probes, it shows high specificity for H2O2 over peroxynitrite (which is much more reactive than H2O2, but exists at much lower abundance).
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from aspirin-based probe AP
Phenotype where environments contain aspirin-based probe AP
Phenotype modified by environments containing aspirin-based probe AP
Human Disease Model