GSK1016790A

Term ID

CHEBI:140524

Synonyms

GSK 1016790A
GSK-1016790A
N-[(2S)-1-(4-{N-[(2,4-dichlorophenyl)sulfonyl]-L-seryl}piperazin-1-yl)-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide
N-[(2S)-1-{4-[(2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide

Definition

A tertiary carboxamide that is piperazine in which one of the amino groups has undergone condensation with the carboxy group of N-[(2,4-dichlorophenyl)sulfonyl]-L-serine, while the other has undergone condensation with the carboxy group of N-(1-benzothiophen-2-ylcarbonyl)-L-leucine. It is a cell-permeable, potent and selective agonist of the TRPV4 (transient receptor potential vanilloid 4) channel.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1-benzothiophenes aromatic primary alcohol dichlorobenzene N-acylpiperazine sulfonamide ... Show All 6 Terms

1-benzothiophenes aromatic primary alcohol dichlorobenzene N-acylpiperazine sulfonamide tertiary carboxamide Show first 5 Terms
has_role: TRPV4 agonist

TRPV4 agonist Show first 5 Terms

Phenotype

Phenotype resulting from GSK1016790A

Phenotype where environments contain GSK1016790A

Phenotype modified by environments containing GSK1016790A

Human Disease / Model Data