ANA-12

Term ID

CHEBI:140465

Synonyms

ANA12
N-{2-[(2-oxoazepan-3-yl)carbamoyl]phenyl}-1-benzothiophene-2-carboxamide
TrkB antagonist

Definition

A secondary carboxamide that is anthranilic acid in which the carboxy group has undergone condensation with the primary amino group of alpha-amino-epsilon-caprolactam, while the aryl-amino group has undergone condensation with the carboxy group of 1-benzothiophene-2-carboxylic acid. It is a selective, non-competitive antagonist of tropomyosin receptor kinase B (TrkB, also known as tyrosine receptor kinase B).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: 1-benzothiophenes caprolactams secondary carboxamide

1-benzothiophenes caprolactams secondary carboxamide Show first 5 Terms
has_functional_parent: 2-aminohexano-6-lactam anthranilic acid

2-aminohexano-6-lactam anthranilic acid Show first 5 Terms
has_role: antidepressant anxiolytic drug tropomyosin-related kinase B receptor antagonist

antidepressant anxiolytic drug tropomyosin-related kinase B receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from ANA-12

Phenotype where environments contain ANA-12

Phenotype modified by environments containing ANA-12

Human Disease / Model Data