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ChEBI

6beta-hydroxycortisol

Term ID
CHEBI:139271
Synonyms
  • (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione
  • 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
  • 6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione
  • 6beta-HO-cortisol
  • 6beta-hydroxycortisol
  • 6beta-OH-cortisol
  • NSC 76163
Definition
A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
References
Ontology
ChEBI  ( EBI )
Resources
CTD
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from 6beta-hydroxycortisol
Phenotype where environments contain 6beta-hydroxycortisol
Phenotype modified by environments containing 6beta-hydroxycortisol
Human Disease Model