Search Ontology:
ChEBI
6beta-hydroxycortisol
- Term ID
- CHEBI:139271
- Synonyms
-
- (6beta,11beta)-6,11,17,21-tetrahydroxypregn-4-ene-3,20-dione
- 6beta,11beta,17,21-tetrahydroxypregn-4-ene-3,20-dione
- 6beta,11beta,17alpha,21-tetrahydroxypregn-4-ene-3,20-dione
- 6beta-HO-cortisol
- 6beta-hydroxycortisol
- 6beta-OH-cortisol
- NSC 76163
- Definition
- A C21-steroid that is cortisol bearing an additional hydroxy substituent at the 6beta-position. In humans, it is produced as a metabolite of cortisol by cytochrome p450-3A4 (CYP3A4, an important enzyme involved in the metabolism of a variety of exogenous and endogenous compounds) and can be used to detect moderate and potent CYP3A4 inhibition in vivo.
- References
-
- CAS:53-35-0
- PMID:14605790
- PMID:16149517
- PMID:16792464
- PMID:17386716
- PMID:19959402
- PMID:20963880
- PMID:21490593
- Reaxys:2512454
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
- has_functional_parent
-
- has_role
-
Phenotype
Phenotype resulting from 6beta-hydroxycortisol
Phenotype where environments contain 6beta-hydroxycortisol
Phenotype modified by environments containing 6beta-hydroxycortisol
Human Disease / Model Data