6-diazo-5-oxo-L-norleucine

Term ID

CHEBI:138889

Synonyms

(S)-2-amino-6-diazo-5-oxocaproic acid
6-diazo-5-oxo-L-norleucine
diazooxonorleucine
L-DON

Definition

A non-proteinogenic L-alpha-amino acid that is L-norleucine which is substituted at position 5 by an oxo group and at position 6 by a diazo group. It is as inhibitor of various glutamine-utilising enzymes.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: diazo compound ketone non-proteinogenic L-alpha-amino acid

diazo compound ketone non-proteinogenic L-alpha-amino acid Show first 5 Terms
has_role: analgesic antibacterial agent antimetabolite antineoplastic agent antiviral agent ... Show All 16 Terms

analgesic antibacterial agent antimetabolite antineoplastic agent antiviral agent apoptosis inducer bacterial metabolite EC 2.4.2.14 (amidophosphoribosyltransferase) inhibitor EC 3.5.1.2 (glutaminase) inhibitor EC 6.3.4.2 [CTP synthase (glutamine hydrolyzing)] inhibitor EC 6.3.5.1 [NAD(+) synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.2 [GMP synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.3 (phosphoribosylformylglycinamidine synthase) inhibitor EC 6.3.5.4 [asparagine synthase (glutamine-hydrolysing)] inhibitor EC 6.3.5.5 [carbamoyl-phosphate synthase (glutamine-hydrolysing)] inhibitor glutamine antagonist Show first 5 Terms
inverse is_tautomer_of: 6-diazo-5-oxo-L-norleucine zwitterion

6-diazo-5-oxo-L-norleucine zwitterion Show first 5 Terms
is_tautomer_of: 6-diazo-5-oxo-L-norleucine zwitterion

6-diazo-5-oxo-L-norleucine zwitterion Show first 5 Terms

Phenotype

Phenotype resulting from 6-diazo-5-oxo-L-norleucine

Phenotype where environments contain 6-diazo-5-oxo-L-norleucine

Phenotype modified by environments containing 6-diazo-5-oxo-L-norleucine

Human Disease Model