Search Ontology:
ChEBI

CBL0137

Term ID
CHEBI:138650
Synonyms
  • 1,1'-{9-[2-(isopropylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone
  • 1,1'-{9-[2-(propan-2-ylamino)ethyl]-9H-carbazole-3,6-diyl}diethanone
  • 3,6-diacetyl-9-(2-isopropylethyl)-9H-carbazole
  • CBL-0137 free base
  • CBLC137
  • Curaxin 137
  • Curaxin-137
Definition
A member of the class of carbazoles that is 9H-carbazole which is substituted by acetyl groups at positions 3 and 6, and by a 2-isopropylethyl group on the nitrogen atom (position 9). It is a modulator of histone chaperone FACT (FAcilitates Chromatin Transcription) - interaction of CBL0137 with the FACT complex results in simultaneous NF-kappa beta suppression, Heat Shock Transcription Factor 1 (HSF1) suppression and p53 activation - and shows antitumour effects in animal models of various cancers.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from CBL0137
Phenotype where environments contain CBL0137
Phenotype modified by environments containing CBL0137
Human Disease / Model Data
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