Search Ontology:
ChEBI
LY-2157299
- Term ID
- CHEBI:137064
- Synonyms
-
- 4-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]quinoline-6-carboxamide
- galunisertib
- galunisertibum
- LY 2157299
- LY2157299
- Definition
- A pyrrolopyrazole that is 5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole which is substituted at positions 2 and 3 by 6-methylpyridin-2-yl and 6-(aminocarbonyl)quinolin-4-yl groups, respectively. A Transforming growth factor-betaRI (TGF-betaRI) kinase inhibitor, it blocks TGF-beta-mediated tumor growth in glioblastoma.
- References
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- CAS:700874-72-2
- KEGG:D10437
- PMCID:PMC3734332
- PMCID:PMC4055765
- PMCID:PMC4652527
- PMID:18039567
- PMID:23826206
- PMID:24868575
- PMID:25424852
- PMID:25488804
- PMID:25529192
- PMID:25573078
- PMID:26057634
- PMID:26137087
- PMID:26309397
- PMID:26526984
- PMID:26902851
- PMID:26976322
- PMID:27197172
- PMID:27509307
- PMID:27756784
- PMID:27990167
- PMID:28230858
- PMID:28405618
- PMID:28436712
- PMID:28451833
- PMID:28481241
- Reaxys:14275134
- Wikipedia:Galunisertib
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
- is a type of
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- has_role
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Phenotype
Phenotype resulting from LY-2157299
Phenotype where environments contain LY-2157299
Phenotype modified by environments containing LY-2157299
Human Disease / Model Data