sapitinib

Term ID

CHEBI:132986

Synonyms

2-(4-{[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxy}piperidin-1-yl)-N-methylacetamide
2-[4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]-N-methylacetamide
AZD-8931
AZD8931
sapitinib
sapitinibum

Definition

A member of the class of quinazolines that is 4-amino-7-methoxyquinazoline in which the amino group has been substituted by a 3-chloro-2-fluorophenyl group and in which position 6 of the quinoline ring has been substituted by a {1-[2-(methylamino)-2-oxoethyl]piperidin-4-yl}oxy group. Sapitinib is a dual tyrosine kinase inhibitor (TKI) of epithelial growth factor receptors (EGFR) HER2 and HER3.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic ether monochlorobenzenes monofluorobenzenes piperidines quinazolines ... Show All 7 Terms

aromatic ether monochlorobenzenes monofluorobenzenes piperidines quinazolines secondary amino compound tertiary amino compound Show first 5 Terms
has_role: EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor epidermal growth factor receptor antagonist

EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor epidermal growth factor receptor antagonist Show first 5 Terms

Phenotype

Phenotype resulting from sapitinib

Phenotype where environments contain sapitinib

Phenotype modified by environments containing sapitinib

Human Disease Model