Search Ontology:
ChEBI

dynasore

Term ID
CHEBI:132754
Synonyms
  • 3-Hydroxynaphthalene-2-carboxylic acid (3,4-dihydroxybenzylidene)hydrazide
  • Dynamin Inhibitor I
  • N'-[(E)-(3,4-dihydroxyphenyl)methylene]-3-hydroxy-2-naphthohydrazide
Definition
A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity of dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_functional_parent
has_role
Phenotype
Phenotype resulting from dynasore
Phenotype where environments contain dynasore
Phenotype modified by environments containing dynasore
Human Disease Model
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