entinostat

Term ID

CHEBI:132082

Synonyms

BAY 86-5274
BAY86-5274
entinostat
entinostatum
MS 27-275
MS 275
MS-27-275
MS-275
N-(2-aminophenyl)-4-(N-(pyridin-3-ylmethoxycarbonyl)aminomethyl)benzamide
N-[[4-[(2-aminoanilino)-oxomethyl]phenyl]methyl]carbamic acid 3-pyridinylmethyl ester
pyridin-3-ylmethyl {4-[(2-aminophenyl)carbamoyl]benzyl}carbamate
SNDX 275
SNDX-275

Definition

A member of the class of benzamides resulting from the formal condensation of the carboxy group of the pyridin-3-ylmethyl carbamate derivative of p-(aminomethyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an inhibitor of histone deacetylase isoform 1 (HDAC1) and isoform 3 (HDAC3).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzamides carbamate ester primary amino compound pyridines substituted aniline

benzamides carbamate ester primary amino compound pyridines substituted aniline Show first 5 Terms
has_functional_parent: 1,2-phenylenediamine

1,2-phenylenediamine Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 3.5.1.98 (histone deacetylase) inhibitor

antineoplastic agent apoptosis inducer EC 3.5.1.98 (histone deacetylase) inhibitor Show first 5 Terms
inverse has_functional_parent: pyridin-3-ylmethyl {4-[(2-amino-4-fluorophenyl)carbamoyl]benzyl}carbamate

pyridin-3-ylmethyl {4-[(2-amino-4-fluorophenyl)carbamoyl]benzyl}carbamate Show first 5 Terms

Phenotype

Phenotype resulting from entinostat

Phenotype where environments contain entinostat

Phenotype modified by environments containing entinostat

Human Disease / Model Data