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ChEBI

1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea

Term ID
CHEBI:131947
Synonyms
  • 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylurea
  • 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-methylphenyl)urea
  • N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N''-(2-methylphenyl)-urea
Definition
A member of the class of indazoles that is linifanib in which the 2-fluoro-5-methylphenyl group has been replaced by a 2-methylphenyl group. A cell-permeable 3-aminoindazolylurea compound, it acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro.
References
Ontology
ChEBI  ( EBI )
Relationships
is a type of
has_role
Phenotype
Phenotype resulting from 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea
Phenotype where environments contain 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea
Phenotype modified by environments containing 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea
Human Disease / Model Data