efavirenz

Term ID

CHEBI:119486

Synonyms

• (-)-6-CHLORO-4-CYCLOPROPYLETHYNYL-4-TRIFLUOROMETHYL-1,4-DIHYDRO-2H-3,1-BENZOXAZIN-2-ONE
• (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
• (S)-6-chloro-4-(cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
• (S)-6-chloro-4-cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one
• 6-chloro-4-(2-cyclopropyl-1-ethynyl)-4-trifluoromethyl-(4S)-1,4-dihydro-2H-benzo[d][1,3]oxazin-2-one
• Efavirenz

Definition

1,4-Dihydro-2H-3,1-benzoxazin-2-one substituted at the 4 position by cyclopropylethynyl and trifluoromethyl groups (S configuration) and at the 6 position by chlorine. A non-nucleoside reverse transcriptase inhibitor with activity against HIV, it is used with other antiretrovirals for combination therapy of HIV infection.

References

• CAS:154598-52-4
• DrugBank:DB00625
• Drug_Central:989
• HMDB:HMDB0014763
• KEGG:C08088
• KEGG:D00896
• LINCS:LSM-5526
• PDBeChem:EFZ
• PMID:10576692
• PMID:10673109
• PMID:25017682
• Patent:EP582455
• Patent:US5519021
• Reaxys:7387333
• Wikipedia:Efavirenz

Ontology

ChEBI  ( EBI )