ZFIN Post-Composed Term: hypothalamus canonical Wnt signaling pathway

Term:	hypothalamus canonical Wnt signaling pathway
Note:	This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name.

Name:	hypothalamus
Synonyms:
Definition:	Multi-tissue structure which is the largest portion of diencephalon and is ventrally located. The hypothalamus arises near the end of the segmentation period and the embryonic hypothalamic region gives rise to the neurohypophysis and other diencephalic nuclei.
Ontology:	Anatomy Ontology [ZFA:0000032]

Name:	canonical Wnt signaling pathway
Synonyms:	canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin
Definition:	A type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Ontology:	GO: Biological Process [GO:0060070] QuickGO AmiGO