| Term: | cerebrospinal fluid contacting neuron apical part of cell |
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| Note: | This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name. |
| Name: | cerebrospinal fluid contacting neuron |
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| Synonyms: | CSF-cN, CSF-cNs |
| Definition: | Spinal cord interneuron located along the central canal that extends a microvilliated apical process into the cerebrospinal fluid and extends ascending axonal projections ventrally and ipsilaterally. CSF-cNs are GABAergic neurons that express PKD2L1 (TRPP3) channels and have been shown to be chemosensory and mechanosensory, responding to pH and osmolarity changes as well as mechanical stimuli associated with tail bending. CSF-cNs originate from two distinct progenitor domains, p3 and pMN. CSF-cNs project onto caudal primary (CaP motor neurons) and commissural primary ascending (CoPA) sensory interneurons within the escape circuit as well as onto V0-v interneurons within the slow swimming circuit. |
| Ontology: | Anatomy Ontology [ZFA:0007120] |
| Name: | apical part of cell |
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| Synonyms: | apical region of cell |
| Definition: | The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue. |
| Ontology: | GO: Cellular Component [GO:0045177] QuickGO AmiGO |