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Phenotype Figure Summary
Marker:
spock1
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
O'Brown
et al.
, 2023
Fig. 1
spock1
hm41/hm41
; s896Tg
, 
spock1
hm43/+
; spock1
hm41/+
; s896Tg
, 
spock1
hm43/hm43
; sj3Tg
brain EGFP expression increased amount, abnormal
brain vasculature increased permeability, abnormal
establishment of blood-brain barrier decreased process quality, abnormal
Fig. 3
spock1
hm41/hm41
brain vasculature blood vessel endothelial cell has extra parts of type blood vessel endothelial cell cytoplasmic vesicle, abnormal
pericyte basement membrane decreased thickness, abnormal
Fig. 4
spock1
hm41/hm41
; s896Tg
brain vasculature basement membrane ab4-col4 labeling decreased amount, abnormal
brain vasculature basement membrane Ab4-fn labeling decreased amount, abnormal
brain vasculature regulation of extracellular matrix organization decreased process quality, abnormal
forebrain metallopeptidase activity increased process quality, abnormal
midbrain metallopeptidase activity increased process quality, abnormal
Fig. 6
spock1
hm41/hm41
; s896Tg
midbrain blood vessel endothelial cell
mcamb
expression decreased amount, abnormal
midbrain pericyte
foxc1b
expression decreased amount, abnormal
midbrain pericyte
mcamb
expression decreased amount, abnormal
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