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Phenotype Figure Summary
Marker:
hmx1
Conditions:
Standard or Control
Publication
Data
Fish
Anatomy
El Fersioui
et al.
, 2022
Figure 1
hmx1
iro2/iro2
vertebra 1 mineralized, abnormal
vertebra 2 mineralized, abnormal
vertebra 3 mineralized, abnormal
vertebra 4 mineralized, abnormal
vertebra bone mineralization premature, abnormal
Figure 2
hmx1
iro3/iro3
vertebra 1 mineralized, abnormal
vertebra 2 mineralized, abnormal
vertebra 3 mineralized, abnormal
vertebra 4 mineralized, abnormal
vertebra bone mineralization premature, abnormal
Figure 3
hmx1
iro2/iro2
whole organism
bmp2b
expression increased amount, abnormal
whole organism
bmp4
expression increased amount, abnormal
whole organism
chrd
expression decreased amount, abnormal
whole organism
nog1
expression decreased amount, abnormal
whole organism
runx2b
expression increased amount, abnormal
whole organism
spp1
expression increased amount, abnormal
Figure 4
hmx1
iro2/iro2
hindbrain
bmp2b
expression increased amount, abnormal
hindbrain
bmp4
expression increased amount, abnormal
hindbrain
runx2b
expression increased amount, abnormal
Figure 5
hmx1
iro2/iro2
vertebra bone mineralization premature, abnormal
El Fersioui
et al.
, 2021
Fig 5
hmx1
iro3/iro3
, 
hmx1
iro2/iro2
eye decreased diameter, abnormal
lens decreased size, abnormal
Fig 6
hmx1
iro3/iro3
brain
uhrf1
expression decreased amount, abnormal
brain
uhrf1
expression decreased distribution, abnormal
pharyngeal arch
uhrf1
expression decreased amount, abnormal
pharyngeal arch
uhrf1
expression decreased distribution, abnormal
retina
uhrf1
expression decreased amount, abnormal
retina
uhrf1
expression decreased distribution, abnormal
whole organism
uhrf1
expression decreased amount, abnormal
Boisset
et al.
, 2012
Fig. 2
WT + MO1-hmx1
eye decreased size, abnormal
lens opaque, abnormal
retina layer formation decreased process quality, abnormal
retina morphogenesis in camera-type eye decreased process quality, abnormal
retinal neural layer absent, abnormal
retinal pigmented epithelium increased thickness, abnormal
Fig. 4
WT + MO1-hmx1
neural retina development delayed, abnormal
retinal cone cell differentiation delayed, abnormal
Fig. 5
WT + MO1-hmx1
brain apoptotic process increased occurrence, abnormal
lens apoptotic process increased occurrence, abnormal
optic cup apoptotic process increased occurrence, abnormal
retina apoptotic process increased occurrence, abnormal
retina cell population proliferation increased occurrence, abnormal
retinal inner nuclear layer cell population proliferation increased occurrence, abnormal
retinal outer nuclear layer cell population proliferation increased occurrence, abnormal
solid lens vesicle apoptotic process decreased occurrence, abnormal
Schorderet
et al.
, 2008
Fig. 6
WT + MO1-hmx1
eye decreased size, abnormal
retina development in camera-type eye disrupted, abnormal
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