Genomic Feature
tk209
- ID
- ZDB-ALT-980413-485
- Name
- tk209
- Synonyms
- Affected Genomic Region
- Construct
- None
- Type
- Allele with one point mutation (1)
- Protocol
- adult males treated with ENU
- Lab of Origin
- Nüsslein-Volhard Lab
- Current Source
- European Zebrafish Resource Center (EZRC) ( order this )
- Other Pages
Notes
No data available
Variants
- Variant Type
- Point Mutation
- Variant Location
- Chr 20: 2027130 (GRCz11) (1) Details
- Nucleotide change
- G/A
- Variant Notes
- None
Effect on DNA/cDNA, transcript, protein (from publications)
- DNA/cDNA Change
- G>A (1)
- Transcript Consequence
- Premature Stop (1)
- Protein Consequence
- Trp>Stop (1)
- Flanking Sequence
-
TATCTGTGTGTGTGTGTGCACGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTATGTCTCTGTGATATATATCTGTGTCTCGCAATATATGACCGTGTGTGTGTCTTATTTATGTGTGTGTGTGTATGTGTGTATATACCTGTGTGTGTGTGTCTGTCTGTGTGTATGTATCTGTGCATGTGTGTGTGTGTGTATGTGCGCTTGTGCGTATATCTGTATATATATATATATATGTGTGTGTGTGTGTGTGTGTTCCTGCAGGTTGGTCATTGAGTTCGAGATGCGCACAGAGACAGACTCTGGTCTGGTTTTCTACATGGCCAGAATAAACCACGCAGACTTCGCCACCATCCAGCTGAAGGAGGGAATGGCTCACCTAAGCTTCGACCTGGGCAGCGGGAACACCTCCGTCAGCGTGCCGCGCATCATCAACGACGGGCAGTG
G/A CACAAGGTCAGTCCGTTAATGAGAAAGTGTAATGTCCCAAAGCTTGAACACTCACACTTCTGTTACACACCTAAAAAGTGTATAGTTGAGGCCAGAATTGAGACGCAGTGTTTGTGATGTGTTGTTGATCATCAGTTTCTCTGTGTAGATCCGTGTGATGAGAGACAAACAGAGAGGAGTCCTCACGATAGACGGCCGCTACAGCAAACACACCACCAGCCCGAAGAAAGCAGAAATCCTGGATGTGGTGGGAATGCTGTATGTTGGTGGTTTACCGCTCAACTACACCACCAAACGCATCGGCCCTGTGAGTACATCACCGAACACAGCTCAATCACAAACACTTCTGTGTGTCGTCAGTTTAAATGTAATGTAATGTAATGTAATGTGTATTATTATAGCGCATTTATTGTGTACGGCCATACACCCAAAGCGCTTCACAATCATGAGCGGGGTCTCTCCACACCACCACCAGTGTGCAGCATCCACTTGGATGATGC - Additional Sequence
- None
Fish
| Fish | Genomic Feature Zygosity | Parental Zygosity | Affected Genomic Regions | Phenotype | Gene Expression |
|---|---|---|---|---|---|
| lama2tk209/tk209 | Homozygous | ♀+/- ♂+/- | Table 1 from Granato et al., 1996 | ||
| lama2tk209 | Unknown | Unknown | Fig. for (tk209) from Phenotype Annotation (1994-2006) |
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Supplemental Information
- Genotyping protocol
- None
- Gupta, V.A., Kawahara, G., Myers, J.A., Chen, A.T., Hall, T.E., Manzini, M.C., Currie, P.D., Zhou, Y., Zon, L.I., Kunkel, L.M., and Beggs, A.H. (2012) A Splice Site Mutation in Laminin-alpha2 Results in a Severe Muscular Dystrophy and Growth Abnormalities in Zebrafish. PLoS One. 7(8):e43794
- Hall, T.E., Bryson-Richardson, R.J., Berger, S., Jacoby, A.S., Cole, N.J., Hollway, G.E., Berger, J., and Currie, P.D. (2007) The zebrafish candyfloss mutant implicates extracellular matrix adhesion failure in laminin {alpha}2-deficient congenital muscular dystrophy. Proceedings of the National Academy of Sciences of the United States of America. 104(17):7092-7097
- Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413
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